This is what I found on DailyMail:
It’s caused an agricultural crisis in the UK. But foot-and-mouth-disease could help treat pancreatic cancer, scientists claim.
A protein from the virus, which causes mouth blisters in animals such as cows, sheep and pigs, was developed into a drug.
It was able to completely rid mice of pancreatic cancer tumours, scientists at Queen Mary University of London said, and even extend their lives.
Sci Tech Daily further explains:
Lead researcher Professor John Marshall, from the Cancer Research UK Barts Centre, explains: “Foot-and-mouth-disease virus uses ΑvΒ6 as a route to infect cattle, as the virus binds to this protein on a cow’s tongue. By testing pieces of the protein in the virus that attaches to ΑvΒ6, we’ve developed a route to deliver a drug specifically to pancreatic cancers. Our previous research had shown that 84 percent of pancreatic cancer patients have high levels of ΑvΒ6 on their cancers.”
The team performed tests of the peptide/tesirine combination in both cells in the laboratory and in mice. They used genetically identical human cancer cells, some that had ΑvΒ6 on their surface and some that had no ΑvΒ6. Both types of cells were exposed to the peptide and drug combination. The cells with ΑvΒ6 were most affected, while the ΑvΒ6 negative cells needed much higher doses of the drug for the cells to be killed.
The tests in mice gave the most impressive results. Mice that had ΑvΒ6-positive tumors were given a tiny dose of the peptide-drug combination three times a week, and this stopped the tumors growing completely. But when the dose was increased and given just twice a week, all tumors in mice that were ΑvΒ6 positive were completely killed.
Professor Marshall called the results “very exciting.”
“One advantage of targeting ΑvΒ6 is that it is very specific to the cancer, because most normal human tissues have little or none of this protein,” Professor Marshall said. “ So we’re hopeful that, if we can develop this into an effective treatment for pancreatic cancer, it would have limited side effects.”
VISIT: Sci Tech Daily for additional details.
ETHealthworld | Scientists target foot, mouth disease virus to tackle pancreatic cancer https://t.co/yJ6mex7T1K
— ETHealthWorld (@ETHealthWorld) February 12, 2020
Information provided by DailyMail.
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